Translator Disclaimer
18 September 2007 Spontaneous transformation of a clonal population of dermis-derived multipotent cells in culture
Author Affiliations +
Abstract
It is reported that adult multipotent stem cells can undergo spontaneous transformation after long-term in vitro culture. Understanding the molecular mechanisms involved in this spontaneous transformation process can help in the design of future therapeutic applications. By far, the transformation process of adult multipotent stem cell is not well understood. In this study, a tumorigenic cell line nominated TDMC1 was established from a clonal population of rat dermis-derived multipotent cells (DMCs) following spontaneous transformation in culture. The transformed cells could produce tumors with characteristics of fibrous histocytoma when they are inoculated subcutaneously into nude mice. The molecular profiles of the nontransformed DMCs and transformed cells were analyzed by a deoxyribonucleic acid microarray. Our results showed that the over-activation of the K-ras/mitogen-activated protein kinase kinase signaling pathway played an important role in the transformation process. These data may be helpful to explain, at least in part, the possible mechanism for the malignant transformation of adult multipotent cells.
Chunmeng Shi, Yue Mai, Ying Zhu, Tianmin Cheng and Yongping Su "Spontaneous transformation of a clonal population of dermis-derived multipotent cells in culture," In Vitro Cellular & Developmental Biology - Animal 43(8), (18 September 2007). https://doi.org/10.1007/s11626-007-9056-y
Received: 19 July 2007; Accepted: 28 July 2007; Published: 18 September 2007
JOURNAL ARTICLE
7 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top