Buprenorphine is a synthetic mixed agonist-antagonist opiate analgesic that is used in a variety of species. To determine if a dose of buprenorphine at 0.1 mg/kg achieves plasma concentrations in parrots that would be analgesic in humans (0.5–1.0 ng/ml), we administered a single dose of buprenorphine (at 0.1 mg/kg) either intramuscularly (5 birds) or intravenously (1 bird) to African grey parrots (Psittacus erithacus erithacus). Serial plasma samples were taken before and at 0.25, 0.5, 0.75, 1.0, 1.5, 2, 6, and 8 hours after administration. For a single intramuscular dose, buprenorphine was rapidly absorbed, and plasma concentrations had a mean residence time of 1.0 hour, elimination half-life of 1.0 hour, and maximum concentration of 68.7 ng/ml, determined by using noncompartmental analysis. This dose of buprenorphine can achieve plasma levels for at least 2 hours in the African grey parrot for comparable analgesic levels in humans, however buprenorphine is not recommended as an analgesic treatment for parrots until pharmacokinetic and analgesia studies are done at higher doses.
You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither BioOne nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the BioOne website.
Vol. 18 • No. 4