Translator Disclaimer
1 September 2010 Determination of an Oral Aflatoxin Dose That Acutely Impairs Hepatic Function in Domestic Pigeons (Columba livia)
Author Affiliations +
Abstract

Aflatoxin B1 is a common hepatotoxin in birds. The goal of this study was to establish an acute model for hepatotoxicosis and decreased hepatic function in the white Carneaux pigeon (Columba livia) via oral administration of this mycotoxin. Aflatoxin B1 was orally administered at a dose of 3 mg/kg dissolved in dimethyl sulfoxide to 3 groups of pigeons every 24 hours for 2, 4, and 6 consecutive days, respectively. Diagnostic modalities used to evaluate hepatic damage and impaired hepatic function pre- and postaflatoxin administration included liver enzyme activity, bile acid levels, scintigraphy, and histopathologic evaluation of liver biopsy specimens. Deaths occurred in all groups, increasing with the number of consecutive days the aflatoxin B1 was dosed. Significant histopathologic lesions were seen on evaluation of hepatic tissue from each group after accumulated aflatoxin exposure (P < .05); therefore, an oral aflatoxin B1 dose of 3 mg/kg given for 2 consecutive days was selected for the purpose of inducing acute hepatic damage while minimizing mortality. However, although increased liver enzyme activity indicated hepatocellular damage at this dosage, bile acids testing and hepatobiliary scintigraphy did not show significantly decreased hepatic function.

Tarah L. Hadley, Judith Grizzle, David S. Rotstein, Shannon Perrin, Lillian E. Gerhardt, James D. Beam, Arnold M. Saxton, Michael P. Jones, and Gregory B. Daniel "Determination of an Oral Aflatoxin Dose That Acutely Impairs Hepatic Function in Domestic Pigeons (Columba livia)," Journal of Avian Medicine and Surgery 24(3), 210-221, (1 September 2010). https://doi.org/10.1647/2008-021.1
Published: 1 September 2010
JOURNAL ARTICLE
12 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top