Leiomyosarcoma is a malignant tumor arising from the smooth muscle of any soft tissue. Occurrence of this tumor in the skeletal muscles is rare. A 6-year-old Larry hen was examined because of lameness in one leg. A firm mass was palpable in its right thigh muscle, and radiographs showed extensive involvement of the surrounding soft tissues. The chicken was euthanatized. At postmortem examination, the primary tumor in the thigh skeletal muscles was firm and pink on its cut surface, and metastatic nodules were observed in the liver, spleen, kidneys, heart, and lungs. On histopathologic examination, the primary mass consisted of elongated spindle cells with eosinophilic cytoplasm and blunt-end nuclei arranged as interwoven bundles. Malignancy of the tumor was determined by the presence of pleomorphism, bizarre cells, and high numbers of mitotic figures. Immunohistochemical staining was positive for vimentin, desmin, and α-smooth muscle actin but negative for myogenin. Leiomyosarcoma was diagnosed based on the histopathologic and immunohistochemical findings. To our knowledge, this is the first report in a fowl of leiomyosarcoma in the skeletal muscle with widespread metastasis to other organs.
You have requested a machine translation of selected content from our databases. This functionality is provided solely for your convenience and is in no way intended to replace human translation. Neither BioOne nor the owners and publishers of the content make, and they explicitly disclaim, any express or implied representations or warranties of any kind, including, without limitation, representations and warranties as to the functionality of the translation feature or the accuracy or completeness of the translations.
Translations are not retained in our system. Your use of this feature and the translations is subject to all use restrictions contained in the Terms and Conditions of Use of the BioOne website.