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1 April 2009 Efficacy of Eprinomectin and Doramectin Against Amblyomma americanum (Acari: Ixodidae) on Cattle
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Abstract

Steers were treated with doramectin or eprinomectin by daily oral capsule for 28 consecutive days. The level of doramectin in the serum of steers treated at 200 µg/kg/d reached a maximum of 104.0 ± 22.1 ppb at day 21 and declined from 93.3 ± 20.5 ppb on the final day of treatment to below detectable by day 56. Steers treated at 50 µg/kg/d reached a maximum level of doramectin in the serum of 24.7 ± 1.2 ppb on day 21 and declined from 24.7 ± 0.6 ppb on the final day of treatment to less than detectable on day 42. Both doramectin dosages provided 100% control of estimated larvae (EL) of Amblyomma americanum (L.) (Acari: Ixodidae) throughout the 28-d treatment period. Daily oral treatment with eprinomectin at a dosage of 200 µg/kg for 28 consecutive days produced a maximum concentration in the serum of 41.6 ± 11.0 ppb at day 14. On the final day of eprinomectin treatment, the serum concentration was 38.3 ± 5.9 ppb. Seven days later at day 35, eprinomectin was not detectable in the serum. For steers treated at 50 µg/kg/d for 28 consecutive days, the serum level of eprinomectin reached a maximum of 10.0 ± 3.0 ppb on day 28 and was undetectable on day 35. Both eprinomectin dosages provided complete control of EL of A. americanum during the 28-d treatment period. Because eprinomectin is efficacious against A. americanum at lower serum levels in cattle and is eliminated from the serum at a more rapid rate than either doramectin or ivermectin, it provides advantages for use in applications such as the medicated bait for control of ticks on white-tailed deer and could have potential for use in the Cattle Fever Tick Eradication Program.

K. H. Lohmeyer, J. A. Miller, J. M. Pound, and D. D. Oehler "Efficacy of Eprinomectin and Doramectin Against Amblyomma americanum (Acari: Ixodidae) on Cattle," Journal of Economic Entomology 102(2), 809-814, (1 April 2009). https://doi.org/10.1603/029.102.0244
Received: 28 November 2008; Accepted: 1 January 2009; Published: 1 April 2009
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