Spinosad bait is used to control western cherry fruit fly, Rhagoletis indifferens Curran (Diptera: Tephritidae), by killing flies before they oviposit. However, effects of different insecticide baits on management of reproductively mature flies are largely unknown. Objectives here were to determine mortality and oviposition of reproductively mature R. indifferens exposed to different insecticide baits for varying periods in the presence and absence of dried yeast extract and sucrose food. Spinosad bait (spinosad in a mix of protein, sugar, and other ingredients) was compared with acetamiprid, thiamethoxam, and imidacloprid in sucrose or Nu-Lure sucrose bait. When flies were exposed to treatments and then offered cherries, Prunus avium (L.) L., for oviposition or when they were exposed to treatments and cherries simultaneously, both thiamethoxam bait and imidacloprid bait resulted in higher mortality and lower oviposition than spinosad bait and acetamiprid bait. Exposures to thiamethoxam bait and imidacloprid bait for six and 24 h were similarly effective, but 6-h exposures to spinosad bait and acetamiprid bait were less effective than 24-h exposures. There was little difference between sucrose and Nu-Lure sucrose baits. When food was present, thiamethoxam bait and imidacloprid bait caused greater mortality and lower oviposition than spinosad bait and acetamiprid bait, but when food was absent, patterns were less consistent. Because of its ability to kill flies sooner after it is exposed to flies when food is present or absent, thiamethoxam or imidacloprid in sucrose or Nu-Lure bait may reduce infestations in cherries more than spinosad bait when mature R. indifferens are present in orchards.