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1 August 2011 Behavioral Responses and Bioefficacy of Some Aromatic Amides Against Aedes aegypti
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Abstract

A series of substituted aromatic amides by varying the chain length, substitution of methyl, methoxy, chloro, and fluoro groups at ortho-, meta-, and para-positions of the phenyl ring of N,N-diethyl-2-phenylacetamide were synthesized. Laboratory studies were carried out to observe the behavioral responses and repellent activity of these newly synthesized aromatic amides against Aedes aegypti (L.) mosquitoes. The deterrent activity of these synthetic amides against any vectors has not been reported previously. These aromatic amides were tested for their behavioral responses and compared with the well known insect repellents, namely, N,N-diethyl toluamide; N,N-diethyl phenylacetamide; and N,N-diethylbenzamide. Out of the 14 compounds synthesized, seven compounds were selected on the basis of those showing >75% of repellent response for the bioefficacy test on human volunteers. The potential use of lead compounds in personal protection management is discussed.

© 2011 Entomological Society of America
A. Garud, K. Ganesan, Shri Prakash, R. Vijayaraghavan, and C. K. Shinde "Behavioral Responses and Bioefficacy of Some Aromatic Amides Against Aedes aegypti," Journal of Economic Entomology 104(4), 1369-1378, (1 August 2011). https://doi.org/10.1603/EC10329
Received: 8 September 2010; Accepted: 1 October 2010; Published: 1 August 2011
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