A 1 yr old male panther chameleon (Furcifer pardalis) was presented with a persistently closed right eye. The ophthalmological examination performed under general anesthesia demonstrated a large corneal ulcer encompassing 50% of the right cornea. Because of the extent of the corneal ulcer and the condition of the eye, the animal was diagnosed as being blind and suffering with severe pain. The authors recommended enucleation to eliminate these symptoms and to avoid any future complications. Two days after surgery, the panther chameleon started hunting on his own. One year after surgery, the panther chameleon is clinically healthy.