A new species of Phyllomedusa, related to Phyllomedusa megacephala, is described from the high plateaus of the state of Goiás and Distrito Federal, Brazil. The new species is characterized by medium size, small finger pads, short and narrow head, thin body, vertical snout in profile, very granulate belly, chest without reticular pattern, transversal bars in the mandible, and flanks with reticular black, sepia, or purple pattern over yellow or orange background.
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