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1 April 2017 The Nuclear Phase of Human Oocytes During ICSI and Nuclear Transfer Procedures
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Abstract

Human oocytes have the aggregated chromosome phase (AC phase) during the first and second meiosis. This needs to be better understood, as the timing of ICSI significantly influences ART outcomes. In fact, performing ICSI after the completion of MII spindle formation is known to improve successful fertilization and embryo development. This human AC phase should also be taken into consideration in the application of nuclear transfer/mitochondrial replacement for patients suffering from severe mitochondrial diseases, to prevent the transmission of these diseases to their offspring, with the aim of limiting the risk of mitochondrial carryover. The possible risks and benefits of AC transfer and other procedures for mitochondrial replacement are reviewed and discussed in this paper.

©2017 Japan Society for Ova Research
Junko Otsuki, Toshiroh Iwasaki, Yuta Tsuji, and Masahide Shiotani "The Nuclear Phase of Human Oocytes During ICSI and Nuclear Transfer Procedures," Journal of Mammalian Ova Research 34(1), 31-36, (1 April 2017). https://doi.org/10.1274/032.034.0106
Received: 21 November 2016; Accepted: 1 December 2016; Published: 1 April 2017
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