Translator Disclaimer
1 October 2018 The Role of Phospholipase in Sperm Physiology and its Therapeutic Potential in Male Infertility
Author Affiliations +
Abstract

In mammals, the role of sperm in the process of fertilization is complex, and several well-defined steps must occur for the sperm to fertilize with the oocyte. Phospholipases (PLs), which regulate the lipid composition of the sperm by hydrolyzation of the phospholipids, are involved in the regulation of the flagellar beat, capacitation, and the acrosomal reaction, as well as in the triggering of the calcium oscillations in the oocyte that lead to oocyte activation. The emerging important role of phospholipases is also revealed by the fact that alterations of sperm lipids can lead to infertility. Phospholipases, especially PLCζ, could represent therapeutic targets to overcome male infertility.

©2018 Japan Society for Ova Research
Fuminori Kimura, Kazumi Kishida, Chisako Horikawa, Mika Izuno, Akiko Nakamura, Jun Kitazawa, Aina Morimune, Shoko Tsuji, Akie Takebayashi, Akiko Takashima, Shoji Kaku, and Takashi Murakami "The Role of Phospholipase in Sperm Physiology and its Therapeutic Potential in Male Infertility," Journal of Mammalian Ova Research 35(2), (1 October 2018). https://doi.org/10.1274/jmor.35.43
Received: 17 June 2018; Accepted: 16 August 2018; Published: 1 October 2018
JOURNAL ARTICLE
10 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top