Translator Disclaimer
1 February 2001 UTILITY OF TUMOR NECROSIS FACTOR-α AND INTERLEUKIN-6 AS PREDICTORS OF NEONATAL MORTALITY IN WHITE-TAILED DEER
Author Affiliations +
Abstract

Blood serum was collected between June 1990 and August 1992 from newborn white-tailed deer (Odocoileus virginianus) fitted with radiocollars. We measured serum concentrations of immunoreactive tumor necrosis factor-α (iTNF-α) and immunoreactive interleukin-6 (iIL-6) to relate cytokine expression to probability of mortality during the first 21 days of life. Stepwise logistic regression indicated that iTNF-α, hemolytic complement, gamma globulins, gamma glutamyl transferase, and mass/length3 could predict survival of white-tailed deer during the first 21 days of life with 90.9% accuracy. Univariate logistic regression did not show a relationship between serum concentrations of iTNF-α or iIL-6 and probability of mortality. However, fawns that died before 21 days of age tended to have greater levels of iTNF-α (688.4 ± 168.8 pg/ml) than survivors (412.9 ± 81.2 pg/ml). Although these data suggest that iTNF-α may be a useful predictor of stress, additional research is needed to understand response of cytokines to neonatal stress and mortality and to elucidate their utility as indices.

Stephen S. Ditchkoff, Michael G. Sams, Robert L. Lochmiller, and David M. Leslie, Jr "UTILITY OF TUMOR NECROSIS FACTOR-α AND INTERLEUKIN-6 AS PREDICTORS OF NEONATAL MORTALITY IN WHITE-TAILED DEER," Journal of Mammalogy 82(1), 239-245, (1 February 2001). https://doi.org/10.1644/1545-1542(2001)082<0239:UOTNFA>2.0.CO;2
Received: 3 January 2000; Accepted: 29 April 2000; Published: 1 February 2001
JOURNAL ARTICLE
7 PAGES

This article is only available to subscribers.
It is not available for individual sale.
+ SAVE TO MY LIBRARY

SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top