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1 February 2012 Peromyscus maniculatus in eastern Colorado: a subspecies with lower prevalence of Sin Nombre virus infection
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Abstract

Data collected over the past 15 years in Colorado show that deer mice (Peromyscus maniculatus) collected in southeastern Colorado have a significantly lower Sin Nombre virus (SNV) antibody prevalence than mice from western Colorado. Based on mitochondrial sequences, P. maniculatus was recently subdivided into 6 clades. Clade 1a occurs throughout the mountainous regions of western Colorado and clade 2 crosses the short-grass steppe in southeastern Colorado. We used mitochondrial single nucleotide polymorphisms (SNPs) from this earlier study and 14 nuclear SNPs to test the hypothesis that clade 2 mice consist of a separate subspecies. Little genetic differentiation was detected (FST  =  0.027) among 435 deer mice collected from 8 locations in western Colorado. In contrast, 171 deer mice collected from 4 locations in eastern Colorado were genetically differentiated from one another (FST  =  0.168) and from those captured in western Colorado (FST  =  0.256). During this survey we identified a single locality in central Colorado where both clade 1a and 2 mice are sympatric and have a high SNV seropositivity (52.2% in 2006; 24.4% in 2009). Antibody prevalence was 21.1% among clade 2 mice, lower than the 32.4% rate among clade 1a mice, suggesting that clade 2 mice may, for both genetic and environmental reasons, have lower susceptibility to SNV infection.

2012 American Society of Mammalogists
Jeffrey B. Doty, Jerry W. Dragoo, William C. Black, Barry J. Beaty, and Charles H. Calisher "Peromyscus maniculatus in eastern Colorado: a subspecies with lower prevalence of Sin Nombre virus infection," Journal of Mammalogy 93(1), 183-197, (1 February 2012). https://doi.org/10.1644/11-MAMM-A-058.1
Received: 18 February 2011; Accepted: 1 August 2011; Published: 1 February 2012
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