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1 March 2000 Repellent and Antifeedant Activity of Salicylic Acid and Related Compounds Against the Biting Midge, Culicoides impunctatus (Diptera: Ceratopogonidae)
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Abstract

An artificial membrane, blood-feeding method was used to assess the repellent and antifeedant effects of derivatives of salicylic acid on the biting midge Culicoides impunctatus Goetghebeur. Trans-2-hydroxycyclohexanecarboxylic acid, 6-methylsalicylic acid, 2,6-dihyrodxy-4-methylbenzoic acid, and salicyluric acid caused highly significant inhibition of feeding, with salicyluric acid performing significantly greater than the other compounds. Investigating the effects of alkyl substitution of salicylic acid, o-thymotic and o-cresotic acids were also effective. A pilot clinical trial using salicyluric acid indicated that it provided a protective effect and it was hypothesized that this may have resulted primarily from contact, because no significant repellent effects were shown for this compound in a microscope slide test, designed to demonstrate repellency with volatile compounds.

A. E. Stuart, C. J W. Brooks, R. J. Prescott, and A. Blackwell "Repellent and Antifeedant Activity of Salicylic Acid and Related Compounds Against the Biting Midge, Culicoides impunctatus (Diptera: Ceratopogonidae)," Journal of Medical Entomology 37(2), 222-227, (1 March 2000). https://doi.org/10.1603/0022-2585-37.2.222
Received: 10 October 1997; Accepted: 1 September 1999; Published: 1 March 2000
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