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1 November 2002 Cross-Resistance to Pyrethroid and Organophosphorus Insecticides Induced by Selection with Temephos in Aedes aegypti (Diptera: Culicidae) from Cuba
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Abstract

A sample of Aedes aegypti (L.) from Santiago de Cuba, Cuba, with a high level of temephos resistance (19.58× at the 50% lethal concentration [LC50]), was subjected to temephos selection to evaluate the utility of this organophosphate insecticide for mosquito control. High resistance developed after six generations of selection (200.00×). Little or no cross-resistance was observed to the organophosphates, malathion and fenitrothion, but high cross-resistance was observed for the pyrethroid deltamethrin (337.5×) and the organophosphate fenthion (12.74×). Synergism tests implicated detoxifying esterases in temephos and fenthion resistance and deltamethrin resistance was associated with a cytochrome P450 monooxygenasa. Biochemical tests, polyacrylamide gel electrophoresis (PAGE), and inhibition studies confirmed the presence of elevated esterase activity associated with temephos resistance. Pyrethroid resistance could be associated with a glutathione-S-transferase mechanism but not the esterases. The cross-resistance to deltamethrin from temephos selection could limit the use of both insecticides for Ae. aegypti control.

María M. Rodríguez, Juan Bisset, Michel Ruiz, and Alaín Soca "Cross-Resistance to Pyrethroid and Organophosphorus Insecticides Induced by Selection with Temephos in Aedes aegypti (Diptera: Culicidae) from Cuba," Journal of Medical Entomology 39(6), 882-888, (1 November 2002). https://doi.org/10.1603/0022-2585-39.6.882
Received: 18 May 2001; Accepted: 1 January 2002; Published: 1 November 2002
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