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1 November 2004 Reinvestigation of an Endogenous Meiotic Drive System in the Mosquito, Aedes aegypti (Diptera: Culicidae)
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Abstract

We have initiated efforts to determine the molecular basis for the MD meiotic drive system in the mosquito, Aedes aegypti. The effect of the MD gene is a highly male-biased sex ratio, but varies depending on the frequency and sensitivity of a susceptible responder ms allele. The MD system has potential as a mechanism for driving trangenes for pathogen resistance into natural Ae. aegypti populations. Because all previously existing laboratory strains carrying the MD gene have been lost, we have selected for a new strain, T37, that carries a strong driver. Matings between T37 males and drive-susceptible ms females result in progeny with highly biased sex ratios, wherein only ≈14.7% females are produced. We discuss the potential for identifying MD candidate genes based on comparisons with the well-described Drosophila melanogaster segregation distorter (SD) meiotic drive system and considerations for release of transgenic Ae. aegypti into natural populations where MD and insensitive mi alleles are likely segregating.

Akio Mori, Dave D. Chadee, Douglas H. Graham, and David W. Severson "Reinvestigation of an Endogenous Meiotic Drive System in the Mosquito, Aedes aegypti (Diptera: Culicidae)," Journal of Medical Entomology 41(6), 1027-1033, (1 November 2004). https://doi.org/10.1603/0022-2585-41.6.1027
Received: 1 April 2004; Accepted: 1 July 2004; Published: 1 November 2004
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