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1 January 2010 Differences in the Salivary Effects of Wild-Caught Versus Colonized Phlebotomus papatasi (Diptera: Psychodidae) on the Development of Zoonotic Cutaneous Leishmaniasis in BALB/c Mice
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Abstract

Preimmunization of mice with salivary gland homogenate (SGH) of long-term colonized (F29) female Phlebotomus papatasi Scopoli (Diptera: Psychodidae) induced protection against Leishmania major Yakimoff & Schokhor (Kinetoplastida: Trypanosomatidae) co-inoculated with the same type of SGH. In contrast, preimmunization of mice with SGH of wild-caught female P. papatasi did not confer protection against L. major co-inoculated with the same type of SGH. Similarly, SGH from recently colonized (F1) female P. papatasi did not protect mice against L. major. These results suggest that when developing a sand fly saliva-based vaccine, the natural vector populations should be considered.

© 2010 Entomological Society of America
S. Ben Hadj Ahmed, I. Chelbi, B. Kaabi, S. Cherni, M. Derbali, and E. Zhioua "Differences in the Salivary Effects of Wild-Caught Versus Colonized Phlebotomus papatasi (Diptera: Psychodidae) on the Development of Zoonotic Cutaneous Leishmaniasis in BALB/c Mice," Journal of Medical Entomology 47(1), 74-79, (1 January 2010). https://doi.org/10.1603/033.047.0110
Received: 31 May 2008; Accepted: 1 September 2009; Published: 1 January 2010
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