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1 September 2010 A High Throughput Screening System for Determining the Three Actions of Insecticides Against Aedes aegypti (Diptera: Culicidae) Populations in Thailand
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Abstract

Chemicals can protect humans from the bites of hemophagous arthropods through three different primary actions: irritancy (excitation), repellency, or toxicity, actions that can be evaluated using a laboratory-based assay system, In this study, the deterrent and toxic actions of three synthetic pyrethroids and DDT were characterized on six field strains of Aedes aegypti from Thailand under laboratory-controlled conditions using the high throughput screening system. All six strains showed significant contact irritant responses to the three synthetic pyrethroids, but significantly weaker irritant responses to DDT, Marked repellency responses were seen in all six Ae. aegypti test strains exposed to DDT, whereas the synthetic pyrethroids resulted in greater toxicity than DDT under similar test conditions. Although significantly different in actions, irritancy and repellency may reflect and be influenced by the background insecticide susceptibility status of a particular mosquito population. Results from this study can be used to guide decision making regarding more effective Ae. aegypti adult control in Thailand.

© 2010 Entomological Society of America
Kanutcharee Thanispong, Nicole L. Achee, John P. Grieco, Michael J. Bangs, Wannapa Suwonkerd, Atchariya Prabaripai, Kamlesh R. Chauhan, and Theeraphap Chareonviriyaphap "A High Throughput Screening System for Determining the Three Actions of Insecticides Against Aedes aegypti (Diptera: Culicidae) Populations in Thailand," Journal of Medical Entomology 47(5), 833-841, (1 September 2010). https://doi.org/10.1603/ME09246
Received: 6 October 2009; Accepted: 1 April 2010; Published: 1 September 2010
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