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1 November 2011 Acute Toxicity Studies of Safer and More Effective Analogues of N,N-Diethyl-2-Phenylacetamide
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Abstract

The present work was designed to evaluate the toxicity of various synthesized aromatic amides that are analogs of N,N-diethyl-2-phenylacetamide, a well known insect repellent. The toxicity profile of these compounds was compared with N,N-diethyl-2-phenylacetamide as well as other registered insect repellents namely N,N-diethyl-3-methyl benzamide and N,N-diethylbenzamide. The primary skin irritation index values of the compounds, dermal toxicity of the chemicals and acute oral toxicity data to assess the safety of the synthesized aromatic amides are reported in this paper. Results of hematological and biochemical studies of these analogues are reported and discussed.

A. Garud, Anshoo Gautam, K. Ganesan, Pravin Kumar, Shri Prakash, P. C. Jatav, Abdesh Kumar, and R. Vijayaraghavan "Acute Toxicity Studies of Safer and More Effective Analogues of N,N-Diethyl-2-Phenylacetamide," Journal of Medical Entomology 48(6), 1160-1166, (1 November 2011). https://doi.org/10.1603/ME10236
Received: 28 October 2011; Accepted: 1 August 2011; Published: 1 November 2011
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