Insecticidal toxicity of extracts from leaves, stems, and bark of Torricellia tiliifolia de Candolle against adult Musca domestica L. and larval Aedes albopictus (Skuse) was evaluated in this study. Bark extract proved to be the most toxic to these two species with the chloroform fraction the most active with LC₅₀ values of 306.15 µg/g and 23.05 µg/ml for the house fly and mosquito, respectively. At the same time, water fractions against M. domestica and petroleum ether against Ae. albopictus were comparatively less toxic. Two compounds from T. tiliifolia extracts, torrilliolide and torricelline, were highly toxic to both species. The LC₅₀ values of torrilliolide and torricelline in adult M. domestica 48 h after topical application were 0.40 and 0.33 µg per adult, respectively, and equal to the commercially available, plant-derived insecticide, rotenone. These results showed that T. tiliifolia possess compounds with considerable bioactivity and worthy of further research.