The last half-century has provided all of the (few) drugs currently used to treat human helminthiases. Concern regarding the long-term utility of these drugs, given how readily resistance evolves in the veterinary-agricultural sector, spurs the discovery of new chemical entities. We review the approaches and technologies in use to identify anthelmintics and discuss a number of drug discovery paradigms that may prove pivotal to the next half-century of anthelmintic development.
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1 April 2015
Anthelmintic Drug Discovery: Into the Future
Timothy G. Geary,
Judy A. Sakanari,
Conor R. Caffrey
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Journal of Parasitology
Vol. 101 • No. 2
April 2015
Vol. 101 • No. 2
April 2015