Translator Disclaimer
1 October 2000 A FACTOR DERIVED FROM ADULT RAT AND COW SMALL INTESTINE REDUCES CRYPTOSPORIDIUM PARVUM INFECTION IN INFANT RATS
Author Affiliations +
Abstract

Cryptosporidium parvum is an intracellular protozoan parasite of the mammalian intestine. In rats, C. parvum infection is age related; infants are susceptible, whereas adults are resistant. The transition from susceptibility to resistance usually takes place around the age of weaning. In the present study, infant rats were orally inoculated with a preparation of intestinal scrapings taken from adult rats or cows. Infant rats received the scrapings daily from 3 to 14 days of age, were inoculated with C. parvum oocysts at 9 days of age, and killed at 15 days of age. Fecal samples and intestinal tissues were examined for the presence of C. parvum. Significantly fewer rats were infected in the groups that received intestinal scrapings compared with controls. In addition, infected rats in the treatment groups shed significantly fewer oocysts than those in the control group. Scrapings from the intestinal mucosa of adult cows were also able to protect infant rats from infection, whereas scrapings from intestines of calves were not protective. In sum, these data indicate the presence of a factor in the intestines of adult rats and cows that can transfer protection against C. parvum infection to susceptible infant rats.

Dhuha Akili and James A. Harp "A FACTOR DERIVED FROM ADULT RAT AND COW SMALL INTESTINE REDUCES CRYPTOSPORIDIUM PARVUM INFECTION IN INFANT RATS," Journal of Parasitology 86(5), (1 October 2000). https://doi.org/10.1645/0022-3395(2000)086[0979:AFDFAR]2.0.CO;2
Received: 20 January 2000; Accepted: 1 May 2000; Published: 1 October 2000
JOURNAL ARTICLE
4 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top