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1 October 2000 B CELLS ARE REQUIRED FOR THE INDUCTION OF INTESTINAL INFLAMMATORY LESIONS IN TCRα-DEFICIENT MICE PERSISTENTLY INFECTED WITH CRYPTOSPORIDIUM PARVUM
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Abstract

Mice with targeted disruptions in the T-cell receptor α gene (TCRα−/−) spontaneously develop inflammatory intestinal lesions with extensive B-cell lamina propria infiltrates. Cryptosporidium parvum infection accelerates intestinal lesion formation in TCRα−/− mice. In the present study, TCRα−/− mice were crossed with JH−/− (B-cell-deficient) mice and challenged with C. parvum to determine if B cells are required for intestinal lesion development. TCRα−/− × JH−/− mice challenged with C. parvum, either as neonates or adults, became persistently infected, whereas TCRα−/ × JH−/ heterozygote control mice cleared the parasite. Cryptosporidium parvum colonization of TCRα−/− × JH−/− mice was heaviest in the distal ileum, with fewer parasites detected in the cecum and distal colon. Despite persistent infection, TCRα−/− × JH−/− mice did not develop inflammatory or hyperplastic intestinal lesions as detected in C. parvum-infected TCRα−/− mice. These findings demonstrate that B cells are a necessary component for the development of inflammatory intestinal lesions of C. parvum-infected TCRα−/− mice.

W. Ray Waters, Mitchell V. Palmer, Michael J. Wannemuehler, Randy E. Sacco, and James A. Harp "B CELLS ARE REQUIRED FOR THE INDUCTION OF INTESTINAL INFLAMMATORY LESIONS IN TCRα-DEFICIENT MICE PERSISTENTLY INFECTED WITH CRYPTOSPORIDIUM PARVUM," Journal of Parasitology 86(5), 1073-1077, (1 October 2000). https://doi.org/10.1645/0022-3395(2000)086[1073:BCARFT]2.0.CO;2
Received: 2 December 1999; Accepted: 1 February 2000; Published: 1 October 2000
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