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1 April 2001 A COMPARATIVE STUDY OF DIFFERENT ALBENDAZOLE AND MEBENDAZOLE REGIMENS FOR THE TREATMENT OF INTESTINAL INFECTIONS IN SCHOOL CHILDREN OF USIGU DIVISION, WESTERN KENYA
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Abstract

A clinical trial to compare the effectiveness of 4- and 6-mo repeated treatment with albendazole 600 mg (Zentel®, SmithKline Beecham) or mebendazole 600 mg (Vermox®, Janssen) on geohelminth infections was carried out on children in 6 primary schools; the study included 1,186 children, ages 4 to 19 yr. Kato–Katz examination was performed on stool samples before and after treatment. Overall, albendazole produced better cure rates and egg reduction rates for geohelminths. The cure rates for albendazole were 92.4% for hookworm infection, 83.5% for Ascaris lumbricoides, and 67.8% for Trichuris trichiura. Mebendazole given either 2 or 3 times in a year had cure rates of 50 and 55.0% (respectively) for hookworm, 79.6 and 97.5% for A. lumbricoides, and 60.6 and 68.3% for T. trichiura infection. The geometric mean intensity of hookworm eggs per gram (epg) of stool decreased by 96.7% after albendazole treatment compared with 66.3 and 85.1%, respectively, for 2 or 3 doses of mebendazole (P < 0.05) over the same period. Reductions in epg for A. lumbricoides and T. trichiura were comparable for both drugs. Our results indicate that treatment with albendazole at a 6-mo interval was more effective than mebendazole regimens and may be the best choice for use in the control of the 3 geohelminths.

Eric M. Muchiri, Fredrick W. Thiong'o, Pascal Magnussen, and John H. Ouma "A COMPARATIVE STUDY OF DIFFERENT ALBENDAZOLE AND MEBENDAZOLE REGIMENS FOR THE TREATMENT OF INTESTINAL INFECTIONS IN SCHOOL CHILDREN OF USIGU DIVISION, WESTERN KENYA," Journal of Parasitology 87(2), (1 April 2001). https://doi.org/10.1645/0022-3395(2001)087[0413:ACSODA]2.0.CO;2
Received: 14 June 1999; Accepted: 1 July 2000; Published: 1 April 2001
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