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1 August 2001 Contemporaneous and Successive Mixed Plasmodium falciparum and Plasmodium vivax Infections Are Associated with Ascaris lumbricoides: An Immunomodulating Effect?
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Abstract

Following an investigation suggesting a protective role for Ascaris against cerebral malaria, possibly through immunomodulation, we examined whether Ascaris had any impact on mixed Plasmodium falciparum and Plasmodium vivax infections. We studied a cross section of 928 patient files between 1991 and 1999. Forty patients had contemporaneous mixed infections and 40 patients had P. falciparum infections, followed by P. vivax infections. There was a significant association between Ascaris infection and risk of having both contemporaneous or successive mixed P. falciparum and P. vivax infections (adjusted odds ratios respectively 6 [2–18] P = 0.001 and 3.6 [1.2–11.1] P = 0.02). There was a positive linear trend between the burden of Ascaris and the risk of mixed infections P < 0.0001. These results suggested the possibility that pre-existing Ascaris infection may increase tolerance of the host to different Plasmodium spp., thus facilitating their coexistence.

M. Nacher, P. Singhasivanon, F. Gay, U. Silachomroon, W. Phumratanaprapin, and S. Looareesuwan "Contemporaneous and Successive Mixed Plasmodium falciparum and Plasmodium vivax Infections Are Associated with Ascaris lumbricoides: An Immunomodulating Effect?," Journal of Parasitology 87(4), (1 August 2001). https://doi.org/10.1645/0022-3395(2001)087[0912:CASMPF]2.0.CO;2
Published: 1 August 2001
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