Translator Disclaimer
1 December 2001 MODULATION OF CAUDAL INTESTINAL PERMEABILITY IN THE RAT DURING INFECTION BY THE TAPEWORM HYMENOLEPIS DIMINUTA
Author Affiliations +
Abstract

Bidirectional movement of solutes between the intestinal lumen and systemic circulation is restricted by tissue barriers that may be altered under conditions such as intestinal infection. In a study using an in vitro everted sac preparation to assess small intestinal permeability in a lumen-to-serosa direction, 51Cr-EDTA movement was compared regionally in the jejunum and ileum of rats infected and uninfected by tapeworms. Whereas jejunal segments showed no significant differences in permeability to 51Cr-EDTA at 6, 15, or 32 days postinfection (dpi), ileal segments displayed an increased permeability on 15 and 32 dpi, but not 6 dpi. The alterations in permeability were not reversed 1 wk after removal of the tapeworm from the intestine. In conclusion, the strictly lumen-dwelling tapeworm infection allows increased movement of molecules from the lumen into ileal, but not jejunal, tissues by 15 dpi.

Noah P. Zimmerman, Paul Bass, and John A. Oaks "MODULATION OF CAUDAL INTESTINAL PERMEABILITY IN THE RAT DURING INFECTION BY THE TAPEWORM HYMENOLEPIS DIMINUTA," Journal of Parasitology 87(6), 1260-1263, (1 December 2001). https://doi.org/10.1645/0022-3395(2001)087[1260:MOCIPI]2.0.CO;2
Received: 27 February 2001; Accepted: 1 April 2001; Published: 1 December 2001
JOURNAL ARTICLE
4 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top