Translator Disclaimer
1 December 2001 High-Resolution Typing of Toxoplasma gondii Using Microsatellite Loci
Author Affiliations +
Abstract

High-resolution typing of Toxoplasma gondii is essential to understand the effect of genetic differences among strains on the variation in disease manifestation and transmission patterns. Current typing methods discern 3 lineages with minimal within-lineage variation. Described here are 6 new variable loci. These loci, including a minisatellite and 5 microsatellites, were more polymorphic than allozymes, restriction fragment length polymorphisms, and sequence variation in introns. Most importantly, these loci revealed, for the first time, substantial within-lineage variation that was over 6-fold higher than that detected by other markers. Genotyping at these loci facilitates classification of isolates beyond the lineage level.

C. R. Blackston, J. P. Dubey, E. Dotson, C. Su, P. Thulliez, D. Sibley, and T. Lehmann "High-Resolution Typing of Toxoplasma gondii Using Microsatellite Loci," Journal of Parasitology 87(6), 1472-1475, (1 December 2001). https://doi.org/10.1645/0022-3395(2001)087[1472:HRTOTG]2.0.CO;2
Published: 1 December 2001
JOURNAL ARTICLE
4 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top