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1 April 2002 EFFECTS OF IVERMECTIN AND ALBENDAZOLE AGAINST ANISAKIS SIMPLEX IN VITRO AND IN GUINEA PIGS
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Abstract

The activity of ivermectin and albendazole against larval Anisakis simplex was tested in vitro and in experimentally infected guinea pigs. Before drug exposure the medium for half of the larvae was adjusted to pH 2.0 with 1 N HCl, whereas the other half was held at pH 7.0. To these solutions, ivermectin was added to full concentrations of 1, 2, 5, 10, 50, 100, or 200 μg/ml, and for albendazole, 300, 400, and 500 μg/ml. Animals from group I were given 0.1 ml of 1% (3.3 mg/kg) ivermectin, whereas guinea pigs from group II were each given 5–7 mg (16.6–23.3 mg/kg) of albendazole orally. The efficacy of both drugs against L3 A. simplex was high in vitro and in vivo against the larvae in different organs of guinea pigs.

Janina Dziekońska-Rynko, Jerzy Rokicki, and Zbigniew Jabłonowski "EFFECTS OF IVERMECTIN AND ALBENDAZOLE AGAINST ANISAKIS SIMPLEX IN VITRO AND IN GUINEA PIGS," Journal of Parasitology 88(2), 395-398, (1 April 2002). https://doi.org/10.1645/0022-3395(2002)088[0395:EOIAAA]2.0.CO;2
Received: 15 August 2000; Accepted: 1 August 2001; Published: 1 April 2002
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