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1 December 2004 MOLECULAR MECHANISMS INVOLVED IN THE DIFFERENTIAL EFFECTS OF SEX STEROIDS ON THE REPRODUCTION AND INFECTIVITY OF TAENIA CRASSICEPS
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Abstract

The in vitro exposure of Taenia crassiceps cysticerci to 17-β estradiol (E2) and progesterone (P4) stimulated their reproduction and infectivity. Testosterone (T4) and dihydrotestosterone (DHT) inhibited their reproduction and reduced their motility and infectivity. E2 and P4 increased, whereas T4 and DHT reduced, the expression of parasite c-fos and c-jun and DNA synthesis. In vitro exposure of cysticerci to sex steroids before their inoculation into recipient noninfected mice resulted in large parasite loads when pretreated with E2 and P4 and in smaller loads when pretreated with T4 and DHT. To determine the possible molecular mechanisms by which sex steroids affect T. crassiceps, sex steroid receptors were amplified. Taenia crassiceps expressed estrogen receptors (both α and β isoforms) and androgen receptors but no P4 receptors. These results demonstrate that sex steroids act directly on parasite reproduction by binding to a classic and specific sex steroid receptor on the parasite. The differential response of cysticerci to sex steroids may also be involved in their ability to grow faster in the murine female or feminized male host. This is the first report of direct sex steroid effects on the parasite possibly through sex steroid receptors in the cysticerci.

Galileo Escobedo, Carlos Larralde, Anahí Chavarria, Marco A. Cerbón, and Jorge Morales-Montor "MOLECULAR MECHANISMS INVOLVED IN THE DIFFERENTIAL EFFECTS OF SEX STEROIDS ON THE REPRODUCTION AND INFECTIVITY OF TAENIA CRASSICEPS," Journal of Parasitology 90(6), 1235-1244, (1 December 2004). https://doi.org/10.1645/GE-297R
Received: 9 December 2003; Accepted: 1 March 2004; Published: 1 December 2004
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