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1 August 2005 Responses of Leishmania (Viannia) braziliensis Cutaneous Infection to N-Methylglucamine Antimoniate in the Rhesus Monkey (Macaca mulatta) Model
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Abstract
The antileishmanial efficacy of the reference drug N-methylglucamine antimoniate (Glucantime®) was evaluated in groups of rhesus monkeys with acute and chronic Leishmania (Viannia) braziliensis cutaneous infection. The therapeutic responses in experimental animals to either a low dose (5 mg/kg body wt/day for 28 days) or a routine dose (20 mg/kg/day for 28 days) of pentavalent antimony were similar to those reported in the human disease. Primates were cured of their lesions after treatment, but with cryptic parasitism and/or relapse. The rhesus model of L. (V.) braziliensis cutaneous leishmaniasis therefore provides an additional resource for preclinical trials with newer drugs.
A. Teva, R. Porrozzi, M. P. Oliveira-Neto and G. Grimaldi Jr. "Responses of Leishmania (Viannia) braziliensis Cutaneous Infection to N-Methylglucamine Antimoniate in the Rhesus Monkey (Macaca mulatta) Model," Journal of Parasitology 91(4), (1 August 2005). https://doi.org/10.1645/GE-3486RN.1
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