Translator Disclaimer
1 August 2006 REFRACTORINESS OF THE WESTERN FENCE LIZARD (SCELOPORUS OCCIDENTALIS) TO THE LYME DISEASE GROUP SPIROCHETE BORRELIA BISSETTII
Author Affiliations +
Abstract
The western fence lizard, Sceloporus occidentalis, is refractory to experimental infection with Borrelia burgdorferi sensu stricto, one of several Lyme disease spirochetes pathogenic for humans. Another member of the Lyme disease spirochete complex, Borrelia bissettii, is distributed widely throughout North America and a similar, if not identical, spirochete has been implicated as a human pathogen in southern Europe. To determine the susceptibility of S. occidentalis to B. bissettii, 6 naïve lizards were exposed to the feeding activities of Ixodes pacificus nymphs experimentally infected with this spirochete. None of the lizards developed spirochetemias detectable by polymerase chain reaction for up to 8 wk post-tick feeding, infected nymphs apparently lost their B. bissettii infections within 1–2 wk after engorgement, and xenodiagnostic I. pacificus larvae that co-fed alongside infected nymphs did not acquire and maintain spirochetes. In contrast, 3 of 4 naïve deer mice (Peromyscus maniculatus) exposed similarly to feeding by 1 or more B. bissettii-infected nymphs developed patent infections within 4 wk. These and previous findings suggest that the complement system of S. occidentalis typically destroys B. burgdorferi sensu lato spirochetes present in tissues of attached and feeding I. pacificus nymphs, thereby potentially reducing the probability of transmission of these bacteria to humans or other animals by the resultant adult ticks.
R. S. Lane, J. Mun, L. Eisen and R. J. Eisen "REFRACTORINESS OF THE WESTERN FENCE LIZARD (SCELOPORUS OCCIDENTALIS) TO THE LYME DISEASE GROUP SPIROCHETE BORRELIA BISSETTII," Journal of Parasitology 92(4), (1 August 2006). https://doi.org/10.1645/GE-738R1.1
Received: 21 September 2005; Accepted: 1 January 2006; Published: 1 August 2006
JOURNAL ARTICLE
6 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top