Translator Disclaimer
1 June 2009 Clinical and Epidemiological Features of Visceral Leishmaniasis and Hiv Co-infection in Fifteen Patients from Brazil
Author Affiliations +
Abstract

Cases of visceral leishmaniasis (VL) in the course of human immunodeficiency virus (HIV) infection have regularly been recorded, mainly in southern Europe. HIV infection can increase the risk of VL development by 10–100 times in endemic areas. We describe the occurrence of this co-infection in 15 patients from Brazil. The mean age of the patients was 38 ± 8.8 yr, with 86.6% males. The mean time between HIV diagnosis and the onset of visceral leishmaniasis was 44 ± 39 mo. The main signs and symptoms presented at admission were splenomegaly (73%), weight loss (73%), cough (67%), fever (67%), asthenia (60%), and diarrhea (60%). The mean T CD4 lymphocyte count was 173.7 ± 225.6 cells/mm3, and viral load was 51,030 ± 133,737/mm3. Treatment consisted of pentavalent antimonials (67% of cases). Most (87%) patients recovered from VL infection; death occurred in 1 patient due to septic shock. VL is an important opportunistic infection in HIV patients, which is potentially fatal, even when correct treatment is completed. Treatment should be done with pentavalent antimonials or amphotericin B in the case of relapse. Although there is no consensus, secondary prophylaxis should be considered in severe cases.

E. F. Daher, P. P. Fonseca, E. S. Gerhard, T. M. J. Silva Leitão, and G. B. Silva Júnior "Clinical and Epidemiological Features of Visceral Leishmaniasis and Hiv Co-infection in Fifteen Patients from Brazil," Journal of Parasitology 95(3), 652-655, (1 June 2009). https://doi.org/10.1645/GE-1678.1
Received: 4 May 2008; Accepted: 1 August 2008; Published: 1 June 2009
JOURNAL ARTICLE
4 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top