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1 April 2013 Imidazole Initiates Exsheathing of L3 Teladorsagia circumcincta
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Abstract
The infective larvae of Teladorsagia circumcincta have a protective sheath that is lost soon after they reach the rumen of the sheep (the definitive host). Incubation in vitro with 50 mM imidazole caused more than 75% of L3 T. circumcincta to begin exsheathing within 2 hr. The initiation of exsheathing was less likely at pH 6.2 than at pH 7.8. The apparent pKa of this process was 7.08, similar to that for the conversion of imidazolium to imidazole. Both the extent and the initial rate of exsheathing initiation increased with imidazole concentration (the apparent K½ was about 50 mM). The initial rate of exsheathing initiation was stimulated by lactose and maltose, but not by some other carbohydrates, and by propylamine and imidazole acetic acid, but not by histidine.
Simon Brown, Jennifer D. Neale, Magnolia Nava-Tirado, Heather V. Simpson, Kevin C. Pedley and David C. Simcock "Imidazole Initiates Exsheathing of L3 Teladorsagia circumcincta," Journal of Parasitology 99(2), (1 April 2013). https://doi.org/10.1645/GE-3051.1
Received: 29 November 2011; Accepted: 1 October 2012; Published: 1 April 2013
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