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1 April 2013 Efficient Iron Uptake via a Reductive Mechanism in Procyclic Trypanosoma brucei
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Abstract
The bloodstream form of Trypanosoma brucei acquires iron from transferrin by receptor-mediated endocytosis. However, it is unknown how procyclic forms that cannot bind transferrin acquire iron. Here, we show that the procyclic form of T. brucei efficiently takes up iron from ferric complexes via a reductive mechanism and that iron obtained using this mechanism is transported to, and used in, the mitochondria. The affinity of the transport system is comparable to that of Saccharomyces cerevisiae, with an apparent Km of 0.85 μM.
Jan Mach, Jan Tachezy and Robert Sutak "Efficient Iron Uptake via a Reductive Mechanism in Procyclic Trypanosoma brucei," Journal of Parasitology 99(2), (1 April 2013). https://doi.org/10.1645/GE-3237.1
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