Infectious pododermatitis (footrot) presumably caused by Spherophorus necrophorus occurred in the left front limb of a mature free-ranging female pronghorn antelope (Antilocapra americana Ord) in southeastern Alberta. Marked swelling of the coronary band, phalanges and metacarpus, with fistulous tracts above the hoof were observed. Tenacious, pale green pus was present in the periarticular tissues but did not involve articular surfaces. The causative organism was grown in pure culture on bovine blood agar, incubated anaerobically at 37 C. This is the first published account of footrot in pronghorns.