One hundred and three Alaskan gray wolves and 12 wolverines were immobilized in the Nelchina and upper Susitna River Basins of southcentral Alaska between March 1977 and May 1981. Sixty five wolves were immobilized with a mixture of phencyclidine HCl and promazine HCl (PP/HCl); 38 wolves were immobilized with etorphine HCl (EHCl) and 12 wolverines were immobilized with EHCl or with a mixture of EHCl and xylazine HCl (XHCl). Phencyclidine HCl is no longer commercially available and an assessment of etorphine HCl as a replacement drug was made. Etorphine HCl dosage of 2.5 mg/wolf proved to be a suitable replacement for PP/HCl for immobilizing wolves while 0.7 mg EHCl with 50 mg XHCl appeared suitable for wolverines.