Population reduction is being used currently to combat skunk rabies in Alberta. A total of 2,398 striped skunks (Mephitis mephitis) were removed from three counties of southern Alberta during 1980–1983 in an effort to combat rabies outbreaks in those areas. The methods employed included trapping, poisoning, and shooting. Skunks in Forty Mile County have been rabies-free for 4 yr and the outbreaks in Newell and Warner counties appear to be under control. The data suggest that population reduction has been effective in controlling rabies in those areas.