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1 April 1987 YOHIMBINE HYDROCHLORIDE REVERSAL OF KETAMINE HYDROCHLORIDE AND XYLAZINE HYDROCHLORIDE IMMOBILIZATION OF BENGAL TIGERS AND EFFECTS ON HEMATOLOGY AND SERUM CHEMISTRIES
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Abstract

Six bengal tigers (Panthera tigris tigris) were immobilized five times at 2-wk intervals with ketamine hydrochloride (ketamine) and xylazine hydrochloride (xylazine) mixtures at different dose levels. Hematology and serum chemistry analyses on blood samples collected at each immobilization remained normal during the study. There were acute changes in hematocrit, chloride, potassium, glucose, and bilirubin as a function of xylazine dose level. The effect of yohimbine hydrochloride (yohimbine) on the depth and duration of immobilization was evaluated in a crossover design with every animal serving as its own control at each dose. Administration of yohimbine resulted in recovery of the animals within 4–8 min in contrast to >60 min with no yohimbine treatment. There were no adverse effects noted with the yohimbine treatment and the tigers did not exhibit a relapse over the next 24 hr. Yohimbine at a dose of 5–15 mg per adult tiger provided effective reversal of 50–150 mg of xylazine per tiger.

Seal, Armstrong, and Simmons: YOHIMBINE HYDROCHLORIDE REVERSAL OF KETAMINE HYDROCHLORIDE AND XYLAZINE HYDROCHLORIDE IMMOBILIZATION OF BENGAL TIGERS AND EFFECTS ON HEMATOLOGY AND SERUM CHEMISTRIES
Ulysses S. Seal, Douglas L. Armstrong, and Lee G. Simmons "YOHIMBINE HYDROCHLORIDE REVERSAL OF KETAMINE HYDROCHLORIDE AND XYLAZINE HYDROCHLORIDE IMMOBILIZATION OF BENGAL TIGERS AND EFFECTS ON HEMATOLOGY AND SERUM CHEMISTRIES," Journal of Wildlife Diseases 23(2), 296-300, (1 April 1987). https://doi.org/10.7589/0090-3558-23.2.296
Received: 8 July 1986; Published: 1 April 1987
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