Five Rocky Mountain bighorn sheep (Ovis canadensis canadensis), approximately 5 mo old and without detectable antibody titers to respiratory syncytial virus (RSV), were assigned to two groups to study the effects of RSV challenge inoculation in vaccinated (n = 3) and unvaccinated (n = 2) bighorns. The three lambs vaccinated with a modified live bovine RSV vaccine developed a detectable antibody response to the vaccine. Vaccinated and unvaccinated lambs challenged with an ovine isolate of RSV developed increased levels of neutralizing antibody, but clinical signs of disease were not observed. Neutralizing antibody titers to RSV remained higher (2–4-fold) in vaccinated lambs over time when compared to unvaccinated lambs.
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1 April 1988
Response of Vaccinated and Unvaccinated Bighorn Sheep (Ovis canadensis canadensis) to Experimental Respiratory Syncytial Virus Challenge
William J. Foreyt,
James F. Evermann
Journal of Wildlife Diseases
Vol. 24 • No. 2
April 1988
Vol. 24 • No. 2
April 1988
Bighorn Sheep
experimental study
Ovis canadensis canadensis
respiratory syncytial virus
serum antibody titer
vaccine