Prevalence of larval nematodes (Ascarops sp., Spirurida, Spirocercidae) and associated granulomata are reported from livers of wild populations of the western fence lizard, Sceloporus occidentalis. Granulomata were circumscribed by layers of fibrocytes. The encysted nematode was surrounded by masses of histiocytes, cellular debris and cells with pyknotic nuclei.