Three attenuated rabies virus vaccines (SAD-B19, ERA/BHK-21, AZA 2) were compared for efficacy and safety in the striped skunk (Mephitis mephitis) by the oral and intranasal routes. The SAD-B19 and ERA/BHK-21 vaccines were given orally; all three vaccines were given intranasally. Oral administration of SAD-B19 and ERA/BHK-21 vaccines induced neither seroconversion nor significant protection against rabies challenge. One skunk which consumed a SAD-B19 vaccine-laden bait succumbed to vaccine-induced rabies. Intranasal instillation of the three vaccines resulted in the deaths of two of six (AZA 2), three of six (ERA/BHK-21) and six of six (SAD-B19) skunks.
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1 January 1990
Ineffectiveness and Comparative Pathogenicity of Attenuated Rabies Virus Vaccines for the Striped Skunk (Mephitis mephitis)
C. E. Rupprecht,
K. M. Charlton,
M. Artois,
G. A. Casey,
W. A. Webster,
J. B. Campbell,
K. F. Lawson,
L. G. Schneider
Journal of Wildlife Diseases
Vol. 26 • No. 1
January 1990
Vol. 26 • No. 1
January 1990
experimental study
Mephitis mephitis
oral vaccination
pathogenesis
rabies
skunk