Thirty-six adult white-tailed deer (Odocoileus virginianus) naturally infected with Fascioloides magna were captured and randomly assigned to four groups. Each group was fed pelleted feed coated with albendazole for each of seven consecutive days to deliver the drug at a dose rate of approximately 0.0, 5.0, 8.5, or 16.5 mg/kg bodyweight/day. At 7 wk posttreatment, each animal was euthanized and necropsied. Effects of albendazole treatment included significant reduction (P < 0.05) in parasite egg count per gram of feces and increase in serum albumin concentration (P < 0.05). Smaller parasites or remains of dead parasites were seen at the end of migratory tracks in the treated groups. Efficacy of the drug was 82 to 84%.