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1 October 1994 COMPARATIVE LEUKOTOXICITIES OF PASTEURELLA HAEMOLYTICA ISOLATES FROM DOMESTIC SHEEP AND FREE-RANGING BIGHORN SHEEP (OVIS CANADENSIS)
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Abstract

Twenty-eight isolates of Pasteurella haemolytica from domestic sheep (n = 14 isolates) and bighorn sheep (n = 14 isolates) were evaluated for leucotoxicity against peripheral blood neutrophils of bighorn sheep by adding bacterial culture supernatants to bighorn sheep neutrophils in vitro. Leukotoxic isolates of P. haemolytica, defined as causing >50% neutrophil death as measured by release of lactate dehydrogenase into culture supernatants, were identified from eight of 14 domestic sheep isolates and from 0 of 14 bighorn sheep isolates. The in vitro assay of isolates of P. haemolytica may provide a valid predictive measure of strain virulence of P. haemolytica, and of potential pneumonic episodes in bighorn sheep populations.

Steven J. Sweeney, Ronald M. Silflow, and William J. Foreyt "COMPARATIVE LEUKOTOXICITIES OF PASTEURELLA HAEMOLYTICA ISOLATES FROM DOMESTIC SHEEP AND FREE-RANGING BIGHORN SHEEP (OVIS CANADENSIS)," Journal of Wildlife Diseases 30(4), 523-528, (1 October 1994). https://doi.org/10.7589/0090-3558-30.4.523
Received: 29 October 1993; Published: 1 October 1994
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