A 1:1 mg mixture of Telazol® and xylazine hydrochloride (100 mg of Telazol® and 100 mg of xylazine per ml) was used to immohilize wild collared peccaries (Tayassu tajacu) and feral hogs (Sus scrofa); mean (±SD) intramuscular dosage rate was 4.73 ± 0.86 mg/kg and 4.35 ± 0.68 mg/kg for peccaries (n = 107) and hogs (n = 49), respectively. Mean (±SD) induction time (time from injection until complete immobilization) was 4.6 ± 2.5 minutes for collared peccaries and 4.4 ± 1.9 for hogs. Peccaries became conscious at 64 ± 29 minutes and first stood at 92 ± 33 minutes after initial injection. Hogs became conscious at 54 ± 26 minutes and first stood at 78 ± 38 minutes after initial injection. A 1:1 mg mixture of Telazol® and xylazine provided an effective and safe method to immobilize both species and provided adequate analgesia and anesthesia for short surgical procedures.