Translator Disclaimer
1 April 2010 EFFECTS OF SEROTONIN AGONISTS AND DOXAPRAM ON RESPIRATORY DEPRESSION AND HYPOXEMIA IN ETORPHINE-IMMOBILIZED IMPALA (AEPYCEROS MELAMPUS)
Author Affiliations +
Abstract
Respiratory depression is a common side effect when opioids are used to immobilize wildlife. Serotonergic ligands have the potential to reverse opioid-induced respiratory depression. We examined whether any of three serotonergic ligands could reverse this depression in etorphine-immobilized (0.07 mg/kg) impala (Aepyceros melampus). The study took place in September–December 2007. Impala received intravenous injections of metoclopramide (10 mg/ kg, n=6), buspirone (0.05 mg/kg, n=8), pimozide (1 mg/kg, n=8), doxapram (1 mg/kg, n=6), and control solutions on separate occasions. During the immobilization, partial pressures of oxygen (PaO2, mmHg) and carbon dioxide (PaCO2, mmHg), respiratory rate (breaths/min), ventilation (l/ min), peripheral O2 saturation (%), tidal volume (l), and respiratory exchange ratio were measured before and after injection of the experimental drugs. Etorphine immobilization caused respiratory depression and hypoxia (mean±SD, PaCO2=51±2 mmHg, PaO2=40±3 mmHg). Metoclopra-mide and buspirone, but not pimozide, attenuated the hypoxic effects of etorphine; 3 min after injection, metoclopramide increased the PaO2 by 7.=66.3 mmHg and buspirone by 666.6 mmHg (F=3.9, P=0.02). These effects were similar to those of doxapram (8±7 mmHg, F=3.9; P>0.05). Neither metoclopramide nor buspirone significantly increased ventilation, but they increased PaO2 by significantly improving the alveolar-arterial oxygen partial pressure gradient (A-a gradient, F=1.4, P<0.05), indicating improved oxygen diffusion. Metoclopramide and buspirone transiently improved blood oxygenation of opioid-immobilized impala, probably by improving ventilation-perfusion ratios, without reversing catatonic immobilization.
Leith C. R. Meyer, Robyn S. Hetem, Linda G. Fick, Duncan Mitchell and Andrea Fuller "EFFECTS OF SEROTONIN AGONISTS AND DOXAPRAM ON RESPIRATORY DEPRESSION AND HYPOXEMIA IN ETORPHINE-IMMOBILIZED IMPALA (AEPYCEROS MELAMPUS)," Journal of Wildlife Diseases 46(2), (1 April 2010). https://doi.org/10.7589/0090-3558-46.2.514
Received: 8 July 2009; Accepted: ; Published: 1 April 2010
JOURNAL ARTICLE
11 PAGES


SHARE
ARTICLE IMPACT
RIGHTS & PERMISSIONS
Get copyright permission
Back to Top