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1 July 2010 THE DUSKY-FOOTED WOODRAT (NEOTOMA FUSCIPES) IS SUSCEPTIBLE TO INFECTION BY ANAPLASMA PHAGOCYTOPHILUM ORIGINATING FROM WOODRATS, HORSES, AND DOGS
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Abstract

The dusky-footed woodrat (Neotoma fuscipes) is the putative reservoir for Anaplasma phagocytophilum in the western United States based on high prevalence of A. phagocytophilum genetic material detected by polymerase chain reaction (PCR), high antibody prevalence, and infestation with the vector tick Ixodes pacificus. Following inoculation of nine wild-caught woodrats with woodrat-, canine-, or equine-origin A. phagocytophilum, all became PCR-positive and seroconverted. However, when PCR-positive woodrat blood was delivered as inoculum to three horses, the horses never became clinically ill, PCR-positive, or antibody-positive. Each horse was subsequently infected with either the equine- or chipmunk-origin A. phagocytophilum, resulting in clinical anaplasmosis. Our data show that woodrats are permissive to several strains of A. phagocytophilum, but strains originating from woodrats did not cause clinical disease in horses.

Nathan C. Nieto, John E. Madigan, and Janet E. Foley "THE DUSKY-FOOTED WOODRAT (NEOTOMA FUSCIPES) IS SUSCEPTIBLE TO INFECTION BY ANAPLASMA PHAGOCYTOPHILUM ORIGINATING FROM WOODRATS, HORSES, AND DOGS," Journal of Wildlife Diseases 46(3), (1 July 2010). https://doi.org/10.7589/0090-3558-46.3.810
Received: 9 September 2009; Accepted: 1 February 2010; Published: 1 July 2010
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