Assessment of Prospective Preventive Therapies for Chronic Wasting Disease in Mule Deer

Lisa L. Wolfe; David A. Kocisko; Byron Caughey; Michael W. Miller

doi:10.7589/0090-3558-48.2.530

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Lisa L. Wolfe,^1,* David A. Kocisko,^2,3 Byron Caughey,² Michael W. Miller¹

¹1 Colorado Division of Wildlife, Wildlife Research Center, 317 West Prospect Road, Fort Collins, Col
²2 Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allerg
³3 Present address: Lilly USA, LLC, 19 Holman Road, Newton, Massachusetts 02466, USA

^* Corresponding author (email: lisa.wolfe@state.co.us)

Abstract

We compared prion infection rates among mule deer (Odocoileus hemionus) receiving pentosan polysulfate, tannic acid, tetracycline HCl, or no treatment 14 days before to 14 days after (dpi) oral inoculation with tonsil tissue homogenate. All deer were infected, but the rapid disease course (230–603 dpi) suggested our challenge was overwhelming.

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Lisa L. Wolfe, David A. Kocisko, Byron Caughey, and Michael W. Miller "Assessment of Prospective Preventive Therapies for Chronic Wasting Disease in Mule Deer," Journal of Wildlife Diseases 48(2), 530-533, (1 April 2012). https://doi.org/10.7589/0090-3558-48.2.530

Received: 8 September 2011; Accepted: 1 November 2011; Published: 1 April 2012

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