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1 October 2015 AGE AND REPEATED BIOPSY INFLUENCE ANTEMORTEM PRPCWD TESTING IN MULE DEER (ODOCOILEUS HEMIONUS) IN COLORADO, USA
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Abstract
Biopsy of rectal mucosa–associated lymphoid tissue provides a useful, but imperfect, live-animal test for chronic wasting disease (CWD) in mule deer (Odocoileus hemionus). It is difficult and expensive to complete these tests on free-ranging animals, and wildlife health managers will benefit from methods that can accommodate test results of varying quality. To this end, we developed a hierarchical Bayesian model to estimate the probability that an individual is infected based on test results. Our model was estimated with the use of data on 210 adult female mule deer repeatedly tested during 2010−14. The ability to identify infected individuals correctly declined with age and may have been influenced by repeated biopsy. Fewer isolated lymphoid follicles (where PrPCWD accumulates) were obtained in biopsies of older deer and the proportion of follicles showing PrPCWD was reduced. A deer's genotype in the prion gene (PRNP) also influenced detection. At least five follicles were needed in a biopsy to assure a 95% accurate test in PRNP genotype 225SS deer.
© Wildlife Disease Association 2015
Chris Geremia, Jennifer A. Hoeting, Lisa L. Wolfe, Nathan L. Galloway, Michael F. Antolin, Terry R. Spraker, Michael W. Miller and N. Thompson Hobbs "AGE AND REPEATED BIOPSY INFLUENCE ANTEMORTEM PRPCWD TESTING IN MULE DEER (ODOCOILEUS HEMIONUS) IN COLORADO, USA," Journal of Wildlife Diseases 51(4), (1 October 2015). https://doi.org/10.7589/2014-12-284
Received: 15 December 2014; Accepted: 1 April 2015; Published: 1 October 2015
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