Setaria yehi Desset, 1966, is reported from domestic reindeer (Rangifer tarandus Linnaeus), maintained at College and Cantwell, Alaska. Microfilariae were present in blood from reindeer harboring S. yehi. Gross and microscopic findings in the infected animals revealed a low-grade peritonitis. Caribou, moose, dairy cows, goats, and dogs examined in the local areas were negative for microfilariae.