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1 March 2000 PHARMACOKINETICS OF PIPERACILLIN AFTER INTRAMUSCULAR INJECTION IN RED-TAILED HAWKS (BUTEO JAMAICENSIS) AND GREAT HORNED OWLS (BUBO VIRGINIANUS)
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Abstract

This study characterized and compared the pharmacokinetics of piperacillin after single 100 mg/kg i.m. injections in nine red-tailed hawks (Buteo jamaicensis) and five great horned owls (Bubo virginianus) over 48 hr by a modified agar well diffusion microbial inhibition assay. The mean maximum plasma piperacillin concentrations were 204 µg/ml and 221 µg/ml for the hawks and owls, respectively, and times of maximum concentrations were 15 min and 30 min, respectively. The calculated mean terminal elimination half-lives were 77 min in the hawks and 118 min in the owls. Area-under-the-curve values were 218 ± 52 µg·hr/ml in the hawks and 444 ± 104 µg·hr/ml in the owls. On the basis of the most common minimal inhibitory concentration (90%) for various bacterial isolates from clinical samples of 8 µg/ml, analysis of the data suggests that the maximum dosing interval for piperacillin at 100 mg/kg in medium sized raptors should be 4–6 hr.

P. K. Robbins, Lisa A. Tell, Martha L. Needham, and Arthur L. Craigmill "PHARMACOKINETICS OF PIPERACILLIN AFTER INTRAMUSCULAR INJECTION IN RED-TAILED HAWKS (BUTEO JAMAICENSIS) AND GREAT HORNED OWLS (BUBO VIRGINIANUS)," Journal of Zoo and Wildlife Medicine 31(1), 47-51, (1 March 2000). https://doi.org/10.1638/1042-7260(2000)031[0047:POPAII]2.0.CO;2
Received: 24 August 1998; Published: 1 March 2000
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